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Cheers vs ZBiotics

Cheers vs ZBiotics: which one fits your night?

Cheers vs ZBiotics compared: Cheers Restore (DHM and L-cysteine), Cheers Relief and ZBiotics Pre-Alcohol by ingredients, timing, format, price and evidence.

Answer firstSource linksLimits included
Editorial visual comparing Cheers and ZBiotics
Editorial context · not a clinical result
Short answer

Cheers and ZBiotics take different approaches. ZBiotics Pre-Alcohol is a probiotic drink with an engineered Bacillus subtilis strain, taken before your first drink. Cheers Restore is a capsule with DHM and L-cysteine, taken after your last drink or before bed, and Cheers Relief is a separate next-day capsule with caffeine. There is no published head-to-head trial, so the useful comparison is timing, ingredients and format, not a winner.

Explore the topic

Three products, three different jobs

Updated · Joyrise Science Team

Joyrise makes a competing DHM product. Cheers details come from cheershealth.com, checked September 26, 2026; ZBiotics details from zbiotics.com, checked September 25, 2026. Prices and formulas change, so check the current labels.

01

Cheers vs ZBiotics at a glance

The biggest difference is when you take each one. ZBiotics is designed for before you drink. Cheers Restore is designed for after the last drink or before bed. Cheers Relief is for the next day. They also differ in what they are: a live probiotic in a small bottle, versus capsule supplements with botanical and amino-acid ingredients. The table below lays out the details from each manufacturer's own pages.

Sources: ZBiotics Pre-Alcohol: probiotic drink and directions; Cheers Restore: ingredients, directions and price; Cheers Relief: ingredients, directions and price

02

ZBiotics Pre-Alcohol: a probiotic you drink first

ZBiotics identifies its organism as Bacillus subtilis ZB183 and describes it as designed to break down acetaldehyde in the gut. ZBiotics scientists published lab work in 2024 showing an engineered strain reduced acetaldehyde in gut-simulated conditions. We did not find a published human trial measuring hangover symptoms. Read our ZBiotics review for the head-to-head, and does ZBiotics work for the evidence in detail.

Sources: ZBiotics Pre-Alcohol: probiotic drink and directions; Hassan-Casarez et al., 2024: Engineering a probiotic B. subtilis for acetaldehyde removal

03

Cheers Restore: DHM and L-cysteine after drinking

Cheers Restore lists DHM (dihydromyricetin) with L-cysteine, and its directions call for three capsules after your last drink or before bed. DHM research is mostly preclinical: a 2026 systematic review found mainly cell and animal studies, plus two small clinical trials of DHM-containing plant extracts rather than isolated DHM. L-cysteine had one small positive placebo-controlled trial in a 2022 systematic review, which rated that evidence very low quality.

Cheers Restore itself has one published human study. In a 2026 observational study, 90 adults who chose when to use it rated their next-day energy, clarity, well-being and sleep slightly better than on alcohol-only nights. It was not randomized or placebo-controlled, and its authors call for a randomized trial to establish cause and effect.

Sources: Cheers Restore: ingredients, directions and price; Skinner et al., 2026: DHM in alcohol-related conditions; Roberts et al., 2022: Pharmacologically active hangover interventions; Song et al., 2026: Observational cohort of Cheers Restore users

04

Cheers Relief is a different product

Cheers Relief is not Restore under another name. Its listed ingredients include white willow bark, ginger, L-theanine (100 mg) and caffeine (50 mg) per dose, and it is meant for the day after drinking. White willow bark is a source of salicylates, so read the warnings if you avoid aspirin, and count the caffeine alongside your coffee. Our Joyrise vs Cheers page covers Restore and Relief in more depth.

Sources: Cheers Relief: ingredients, directions and price

06

Can you take Cheers and ZBiotics together?

No study has tested the combination. Because they are taken at different times and contain different ingredients, some people consider both, but stacking products does not make more drinking safe. Read both labels in full, check for overlap with anything else you take, such as caffeine or aspirin-like ingredients, and ask a pharmacist if you take medicines.

Sources: Cheers Relief: ingredients, directions and price; ZBiotics Pre-Alcohol: probiotic drink and directions

07

Where Joyrise fits

Joyrise is a DHM product like Cheers Restore, with different directions and its own formula. Joyrise is an Alcohol Metabolizing Aid: a DHM supplement built around dihydromyricetin. The capsule label says to take 3 capsules while consuming alcohol, or before bed. Do not exceed 3 servings (9 capsules) per day. Much of the alcohol-related DHM evidence is preclinical, and Joyrise does not lower BAC, reverse impairment, or make driving safe. Read the full directions and warnings on our Alcohol Metabolizing Aid capsules page before you buy.

Sources: Joyrise capsules: product page and current label; Shen et al., 2012: DHM and alcohol-related signaling; Dihydromyricetin: evidence and safety context

Cheers vs ZBiotics, from each manufacturer's own pages
FeatureZBiotics Pre-AlcoholCheers RestoreCheers Relief
CategoryProbiotic drinkCapsule supplementCapsule supplement
Key ingredientsBacillus subtilis ZB183DHM, L-cysteineWhite willow bark, ginger, L-theanine, caffeine
When to takeBefore drinkingAfter the last drink or before bedThe day after drinking
FormatReady-to-drink bottle3 capsules per serving3 capsules per serving
Listed price (checked)See zbiotics.com$35 for 12 doses (Sept 26, 2026)$35 for 12 doses (Sept 26, 2026)
Published human study of the product (PubMed, Oct 18, 2026)None found; lab study onlyOne observational study (2026), not randomizedNone found

Read the sources.

Public-health guidance, peer-reviewed studies, and current labels provide different kinds of evidence. Manufacturer descriptions establish product details, not clinical results.

Manufacturer · checked September 25, 2026ZBiotics Pre-Alcohol: probiotic drink and directionsZBiotics Company lab study (PLoS One) · PubMed 39509360Hassan-Casarez et al., 2024: Engineering a probiotic B. subtilis for acetaldehyde removalManufacturer · checked September 26, 2026Cheers Restore: ingredients, directions and priceManufacturer · checked September 26, 2026Cheers Relief: ingredients, directions and priceObservational study (Nutrients) · PubMed 42588049Song et al., 2026: Observational cohort of Cheers Restore usersSystematic review (Nutrients) · PubMed 42514290Skinner et al., 2026: DHM in alcohol-related conditionsSystematic review (Addiction) · PubMed 34972259Roberts et al., 2022: Pharmacologically active hangover interventionsNIH LiverToxDihydromyricetin: evidence and safety contextJoyrise · product informationJoyrise capsules: product page and current label

Frequently asked questions

Is Cheers or ZBiotics better?

There is no head-to-head trial, so neither can be called better. They are different products: ZBiotics is a probiotic drink taken before alcohol, Cheers Restore is a DHM and L-cysteine capsule taken after the last drink or before bed.

What is the difference between Cheers and ZBiotics?

Ingredients, format and timing. ZBiotics uses an engineered Bacillus subtilis strain in a ready-to-drink bottle. Cheers Restore uses DHM and L-cysteine in capsules, and Cheers Relief is a separate next-day formula with caffeine.

Can you take Cheers and ZBiotics together?

No study has tested the combination. Read both labels, check for overlapping ingredients such as caffeine, and ask a pharmacist if you take medicines. Combining products does not make more drinking safe.

Does Cheers Restore have DHM?

Yes. Cheers lists DHM and L-cysteine as Restore's ingredients, with three capsules after the last drink or before bed.

When do you take ZBiotics vs Cheers?

ZBiotics is taken before drinking. Cheers Restore is taken after your last drink or before bed. Cheers Relief is taken the next day.

Do Cheers or ZBiotics lower blood alcohol?

We do not attribute that to either, and no supplement or drink lowers BAC. Only time does. Neither makes it safe to drive.

Keep reading

Does ZBiotics work?Joyrise vs Cheers: Restore and ReliefZBiotics alternatives: Joyrise vs ZBioticsWhat to take before drinking

Joyrise Alcohol Metabolizing Aid. One labeled serving.

Read the label, then choose your format.

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Joyrise does not reduce impairment or BAC and does not make drinking safer. Never drink and drive.

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