Botanical source
Dihydromyricetin occurs in Ampelopsis grossedentata, commonly called vine tea, and in Hovenia dulcis, the Japanese raisin tree. Source identity and standardization matter when comparing ingredients.
Dihydromyricetin
What is DHM (dihydromyricetin)?
Botanical identity, research, and sources.
DHM (dihydromyricetin) is a plant flavonoid found in vine tea and Japanese raisin tree. This page explains its identity, botanical sources, and research limitations.
Short answer
DHM is a plant flavonoid found in vine tea. Researchers have studied it in alcohol-related, antioxidant, metabolic, and neural-signaling models. Much of the evidence is preclinical, so a mechanism in a cell or animal is not the same as a proven finished-product result in people. After this definition, use the best DHM supplement scorecard to compare formulated capsules with raw DHM.
The molecule
One ingredient. Several evidence layers.
Molecule
DHM is a flavonoid. The name on a label does not tell you its source, purity, formulation, or how much reaches circulation.
Research model
Cell, rodent, and limited human evidence should be labeled separately. They do not carry the same certainty.
What researchers are actually studying.
Pathways are not promises. Each finding needs its model, dose, route, and endpoint attached.
Preclinical studies examine enzymes involved in the conversion of ethanol to acetaldehyde and then acetate. Findings are not a shortcut around time.
The widely cited 2012 UCLA paper used rodent and cell models. It did not test a finished Joyrise product in a human clinical trial.
Researchers have examined antioxidant-response and autophagy pathways, mostly in preclinical settings. Human outcome evidence remains limited.
Why formulation matters
DHM on a label is only the beginning.
Raw DHM has known solubility and absorption challenges in preclinical research. Joyrise uses a patented delivery approach designed around bioavailability. The patent protects an invention. It does not guarantee that every person will experience the same result.
- Compare source and formulation
- Read the exact serving directions
- Ask whether evidence is human, animal, or cell
- Keep responsible-use limits visible
Read a DHM study in four steps.
Updated September 9, 2026. Keep the experiment attached to the conclusion.
Vine tea extract contains more than one substance. A number beside the extract name is not automatically the amount of DHM. Standardization describes the measured proportion of a constituent; identity and purity testing answer different questions from absorption testing. Use the full Supplement Facts panel to see what the stated serving actually supplies. NIH LiverTox describes DHM and its botanical sources.
The influential 2012 Shen study used rat and cell models, including injected DHM in its animal experiments. It examined alcohol-related behavior and GABA-A signaling. Injection bypasses parts of the digestive process. Neither the species nor the administration route matches a person taking a capsule, so its experimental dose is not a consumer serving instruction.
A 2021 mouse study compared oral and injected DHM and measured the compound and its metabolites in serum and brain. Different exposure after different routes helps explain why formulation deserves research. It does not show that every liquid, capsule, or patented formula produces a particular human result. Ask for the same formulation, dose, comparator, and measurement when reading an absorption claim.
A 2015 randomized trial studied 60 adults with nonalcoholic fatty liver disease over three months, using oral DHM and measuring metabolic and liver-related markers. This is human research, but it does not test a hangover outcome or the Joyrise formula. Before transferring a finding, check the participants, treatment duration, other ingredients, and endpoint. A change in a blood marker is not interchangeable with symptom relief, disease prevention, or better daily performance.
Primary sources
Read the methods before the headline.
DHM questions, answered plainly.
What is DHM?
DHM, or dihydromyricetin, is a naturally occurring flavonoid found in plants including vine tea and Japanese raisin tree.
What has DHM been studied for?
Researchers have studied DHM in alcohol-related pathways, GABA-A signaling, oxidative-stress responses, and metabolic models. Much of the alcohol-related evidence is from cells and animals.
Does DHM lower BAC or make drinking safe?
No. DHM does not lower BAC or impairment, does not make drinking safer, and must never be used as a reason to drive after drinking.
Are all DHM supplements the same?
No. Source, dose, delivery system, other ingredients, format, testing, and directions can differ. Compare the current labels, not only the front-of-pack milligram number.
Is vine tea extract the same as a stated amount of DHM?
Not necessarily. Extract weight describes the whole extract; a declared DHM amount describes the compound. Check the plant identity, amount per serving, and any stated standardization before treating two labels as equivalent.
Does human liver research prove a hangover benefit?
No. Trials in people with specific metabolic liver conditions study different populations and endpoints. They do not establish a next-morning benefit from a finished Joyrise product in otherwise healthy social drinkers.
Ready to compare formats?
Bottle, packets, or powder.
Joyrise does not reduce impairment or BAC and does not make drinking safer. Never drink and drive.